The effectiveness of deferasirox to prevent from the occurrence of liver fibrosis in balb/c mice with iron overload

Background: Oxidation of hepatocyte mitochondria due to iron overload led injury, elevated Transforming growth factor- β (TGF- β), and fibrosis. Fibrosis starts with stellate cell fibrogenesis activated by chronic injury. Liver fibrosis is the main cause morbidity mortality in overload. Deferasirox an chelation drug serving bind have antifibrotic effect. Aim: To examine effect deferasirox on liver prevention Methods: This experimental research used a post-test only control group design male Balb/c mice that were randomly divided into 3 groups, each n=5. Group 1 (NaCl+S) was administered 0.3 cc Na Cl 0.9% through intra peritoneal (I.P) injection solvent (Aquabidest, CMC Nipagin) per oral (P.O) intermittently. 2 (Fe+S) 1.5 mg Fe+sucrose (Venofer®) I.P P.O (Fe+Dfx) injection, 20 mg/kgBW/day All treatments given for 60 days. The area fraction liverwas assessed using software ImageJ. Results: average 0.00 ± 0.00%, 9.17 8.54% 1.38 0.20%. fractions between groups significantly different p value 0.000 (p<0.05). body weight higher than 1. Conclusions: Iron causes mice. administration may lower Bangladesh Journal Medical Science Vol. 22 No. 01 January’23 Page : 84-90